N-Acetyl Cysteine (NAC)

N-Acetyl Cysteine (NAC) is well-known for its antioxidant properties. It acts as a precursor to glutathione, which is one of the body’s most potent antioxidants and has a huge role in male fertility.

1. Antioxidant activity: A randomized controlled trial of men taking NAC supplements daily for 3 months found a significant increase in the total antioxidant capacity and significant less oxidative stress compared to men taking placebo
2. Improves semen volume: Research shows men taking NAC supplements daily for 3 months had a 1 mL improvement in semen volume compared to controls¹.
3. Improves sperm motility: Research demonstrates almost a 50% improvement in sperm motility in men taking NAC supplements daily for 3 months^1.
4. Improves testosterone: A second randomized trial of men taking NAC supplements daily for 3 months identified 60-unit increase in testosterone levels². Normal testosterone is important for sperm production
5. Improves sperm concentration: Some research has shown a 15% increase in sperm concentration in men taking NAC supplements daily for 3 months compared to placebo².

References:

1. Ciftci H, Verit A, Savas M, Yeni E, Erel O. Effects of N-acetylcysteine on semen parameters and oxidative/antioxidant status. Urology. 2009;74(1):73-76. doi:10.1016/j.urology.2009.02.034
2. Safarinejad, M. R., & Safarinejad, S. (2009). Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study. The Journal of urology, 181(2), 741–751. https://doi.org/10.1016/j.juro.2008.10.015