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Integrating probiotics to
What is the gut-testis axis?
There is emerging literature assessing the role of the gut in male reproductive health, specifically the semen microbiome profile in men who have subfertility compared to men with normal fertility.
What is the microbiome?
The human microbiome refers to the complex ecosystem of bacteria, viruses, and fungi living on and in the human body, which are pivotal to our well-being.
A landmark study published in European Urology in 2021 identified a disruption in the gut and semen microbiome, specifically increased seminal Aerococcus and decreased rectal Anaerococcus in infertile men. Association does not necessarily imply causation, but this has sparked further studies assessing normalizing and improving the gut microbiome to optimize male reproductive health.
Probiotics, which are beneficial bacteria that promote a healthy gut microbiome, have also been increasingly studied for their potential impact on male fertility.
Here's a summary of the key points regarding the impact of probiotics on male fertility:
Improves sperm quality: increased ejaculate volume, sperm count, and motility
Reduces oxidative stress in the testicle and improves sperm DNA integrity
A double-blind randomized placebo-controlled compared the impact of a daily probiotic for 10 weeks in 25 men with subfertility (low sperm counts, low motility, and abnormal morphology). Men in the study were on average 32 years old. At the end of the study, compared to men who received a placebo they noted increased ejaculate volume (5 cc vs. 3.8 cc), increased sperm concentration (20 million/cc vs. 16 million/cc), and increased sperm motility (26% vs. 18%). From baseline, men who took a daily probiotic had overall improved total sperm counts by 22 million/ejaculate. The levels of oxidative stress and inflammation were also significantly improved in the probiotic-treatment group compared to men who received controls. Why is reduced oxidative stress and normalized sperm DNA integrity important? Elevated sperm DNA damage levels can be associated with poor pregnancy outcomes, recurrent miscarriages, and recurrent IVF failure.
What probiotics were specifically used in the study?
A combination of 2 billion CFU of Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus bulgaricus, Lactobacillus acidophilus, Bifidobacterium breve, Bifidobacterium longum, Streptococcus thermophiles. All of which are included in our capsule in addition to more and 6x more billion colony forming units!
Other benefits seen with probiotics:
Improves hormonal balance: Probiotics have been linked to optimized testosterone production, which is essential for spermatogenesis (sperm production) and overall male reproductive health
Immune system modulation: Probiotics can modulate the immune response and reduce inflammation in the reproductive tract, creating a more favorable environment for sperm health and function
General well-being: Probiotics support overall well-being, including better digestion, nutrient absorption, and immune function, all of which can indirectly support reproductive health
